Low-income areas increase risks for diabetic children

Low-income areas increase risks for diabetic children

Deladoëy J, Henderson M, Geoffroy L. Linear association between household income and metabolic control in children with insulin-dependent diabetes mellitus despite free access to health care. J Clin Endocrinol Metab 2013 (accepted). Highlighted by an article in lay journal The Gazette (5 April 2013), the main English daily journal of the city of Montreal.   … Continue reading »

Gene modifiers explain differences in severity of disease

Gene modifiers explain differences in severity of disease

Hasselmann C, Deladoëy J, Vuissoz JM, Patry JM, Alirezaie N, Schwartzentruber J, Deal CL, Van Vliet G, Majewski J, Samuels M. Expanding the phenotypic spectrum of nicotinamide nucleotide transhydrogenase(NNT) mutations and using whole exome sequencing to discover potential disease modifiers. J Genomes Exomes 2013; 1: 19-30 (doi: 10.4137/JGE.S11378) open access at http://www.la-press.com

Treating Congenital Hypothyroidism in Infants and Children: which levothyroxine?

Treating Congenital Hypothyroidism in Infants and Children: which levothyroxine?

Deladoëy J and Van Vliet G. Treating Congenital Hypothyroidism: which levothyroxine? Nat Rev Endocrinol 2013 (Epub 5 March 2013) Importantly, parents of infants with congenital hypothyroidism must be reassured that, provided that their infant’s serum TSH concentration is not markedly raised after the first 2 weeks of treatment and that monitoring at regular intervals occurs, … Continue reading »

Personalized medicine eliminates need for drug in two children

Personalized medicine eliminates need for drug in two children

Samuels ME, Gallo-Payet N, Pinard S, Hasselman C, Magne F, Patry L, Chouinard L, Schwartzentruber J, René P, Sawyer N, Bouvier M, Djemli A, Delvin E, Huot C, Eugene D,Deal CL, Van Vliet G, Majewski J, Deladoëy J. Bioinactive ACTH Causing Glucocorticoid Deficiency. J Clin Endocrinol Metab 2013; 98: 736-742. Highlighted by an article in … Continue reading »

calitonin cells where you don’t except them !!!

calitonin cells where you don’t except them !!!

Vandernoot I, Sartelet H, Abu-Khudir R, Chanoine JP, Deladoëy J. Evidence for calcitonin-producing cells in human lingual thyroids. J Clin Endocrinol Metab 2012; 97: 951-956. A lingual thyroid results from the failure of the thyroid precursor cells to migrate from the primordial pharynx to the anterior part of the neck. Fusion of the ultimobranchial bodies … Continue reading »

Fetal Goiter

Fetal Goiter

Stoppa-Vaucher S, Van Vliet G, Deladoëy J. Discovery of a fetal goiter on prenatal ultrasound in women treated for Graves’ disease: First, do not harm. Thyroid 2011; 21: 931. This article reports on the monitoring of a pregnant woman whose 19-week-old fetus presented a goiter revealed by ultrasound. The mother’s thyroid function was normal, whereas … Continue reading »

congenital hypothyroidism: becoming more frequent ?

congenital hypothyroidism: becoming more frequent ?

Deladoëy J, Ruel J, Giguère Y, Van Vliet G. Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Québec. J Clin Endocrinol Metab 2011; 96: 2422–2429. Highlighted by an editorial (J Clin Endocrinol Metab 2011; 96: 2395–2397). Induced a change in screening protocol in Quebec (higher threshold for 2nd test … Continue reading »

Variation by Ethnicity in the Prevalence of Congenital Thyroid Malformation

Variation by Ethnicity in the Prevalence of Congenital Thyroid Malformation

Stoppa-Vaucher S, Van Vliet G, Deladoëy J. Variation by Ethnicity in the Prevalence of Congenital Hypothyroidism due to Thyroid Dysgenesis. Thyroid 2011; 21(1):13-8. Thyroid dysgenesis is less prevalent in Blacks and more prevalent in Caucasians. Blacks being more genetically diverse, this suggests oligogenic mechanisms accounting for thyroid dysgenesis.

Gene expression of ectopic thyroids

Gene expression of ectopic thyroids

Abu-Khudir R, Paquette J, Lefort A, Libert F, Chanoine JP, Vassart G, Deladoëy J. Transcriptome, Methylome and Genomic Variations Analysis of Ectopic Thyroid Glands. PLoS ONE 2010; 5(10): e13420 Highlighted by the Target Intelligence Service (TIS), a database used by pharmaceutical companies to identify groundbreaking research of relevance for their own work on potential drug … Continue reading »