Fish to study the development of the thyroid

Functional Zebrafish Studies Based on Human Genotyping Point to Netrin-1 as a Link between Aberrant Cardiovascular Development and Thyroid Dysgenesis Endocrinology 2015 Careful phenotyping of patients combined with molecular and functional studies in zebrafish identify Netrin-1 as a potential shared genetic factor for cardiac and thyroid congenital defects. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272402/

Epigenetic and the thyroid

Epigenetic and the thyroid

Role for tissue-dependent methylation differences in the expression of FOXE1 in non-tumoral thyroid glands (JCEM 2014) The main outcome of the present study supports the concept that DNA methylation plays a role in the differential expression of the thyroid transcription factor FOXE1 in normal leukocytes (cells that do not express FOXE1) and in the thyroid, … Continue reading »

Low-income areas increase risks for diabetic children

Low-income areas increase risks for diabetic children

Deladoëy J, Henderson M, Geoffroy L. Linear association between household income and metabolic control in children with insulin-dependent diabetes mellitus despite free access to health care. J Clin Endocrinol Metab 2013 (accepted). Highlighted by an article in lay journal The Gazette (5 April 2013), the main English daily journal of the city of Montreal.   … Continue reading »

Treating Congenital Hypothyroidism in Infants and Children: which levothyroxine?

Treating Congenital Hypothyroidism in Infants and Children: which levothyroxine?

Deladoëy J and Van Vliet G. Treating Congenital Hypothyroidism: which levothyroxine? Nat Rev Endocrinol 2013 (Epub 5 March 2013) Importantly, parents of infants with congenital hypothyroidism must be reassured that, provided that their infant’s serum TSH concentration is not markedly raised after the first 2 weeks of treatment and that monitoring at regular intervals occurs, … Continue reading »

a mutation in TPO

a mutation in TPO

Deladoëy J, Pfarr N, Vuissoz JM, Parma J, Vassart G, Biesterfeld S, Pohlenz J, Van Vliet G. Pseudodominant inheritance of goitrous congenital hypothyroidism caused by TPO mutations: molecular and in silico studies. J Clin Endocrinol Metab 2008; 93: 627-633. We reported a pedigree presenting with pseudodominant goitrous CH due to segregation of three different TPO … Continue reading »